BME Researchers Lead $24M Project Using mRNA to ‘Turn On’ Helpful Immune Responses

President Joe Biden and the White House for a team led by ɫ and Emory University biomedical engineers who want to use mRNA to unlock new treatments for cancer and other chronic diseases.

Their project, called Curing the Uncurable via RNA-Encoded Immunogene Tuning (CUREIT), aims to use mRNA to essentially turn genes on or off in individual immune cells. The idea is to reverse the suppression or dysregulation of the immune system that is common in chronic diseases like cancer.

“By combining mRNA-encoded antigens with gene modulation technology, we will be able to radically enhance specific immune responses,” said , the project’s leader and a professor in the . “This technology, which operates transiently without modifying DNA, can offer a potential breakthrough in treating cancers, autoimmune disorders and infectious diseases.”